Publications

Rashid S, Wong C, Roy R. (2021) Developmental plasticity and the response to nutrient stress in Caenorhabditis elegans Dev Biol. 2021 Jul;475:265-276.

Wong C., Roy R. (2020) AMPK Regulates Developmental Plasticity through an Endogenous Small RNA Pathway in Caenorhabditis elegans. International Journal of Molecular Sciences 21: 6. doi: https://doi.org/10.3390/ijms21062238

Schmeisser S., Li S., Bouchard B., Ruiz M., Rosiers C.D., Roy R. (2019) Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling. Cell Reports 29: 13. doi: https://doi.org/10.1016/j.celrep.2019.11.090.

Kadekar P. and Roy R. (2019) AMPK regulates germline stem cell quiescence and integrity through an endogenous small RNA pathway. PLoS Biol 17: 6. doi: 10.1371/journal.pbio.3000309.

Kadekar P., Chaouni R., Clark E., Kazanets A., Roy R. (2018) Genome-wide surveys reveal polarity and cytoskeletal regulators mediate LKB1-associated germline stem cell quiescence. BMC Genomics 19: 462. doi: 10.1186/s12864-018-4847-y.

Demoinet E., and Roy, R. (2018) Analysis of Transgenerational Phenotypes Following Acute Starvation in AMPK-Deficient C. elegans. Methods Mol Biol. 1732: 565. doi: 10.1007/978-1-4939-7598-3_36.

Demoinet E., and Roy, R. (2018) Surviving Starvation: AMPK blocks starvation-inducible transgenerational defects. Bioessays 40. doi: 10.1002/bies.201700095.

Demoinet E, Li, S., and Roy, R. (2017) AMPK blocks starvation-inducible transgenerational defects. Proc Natl Acad Sci 114, e2689-2698 doi: 10.1073/pnas.1616171114.

Ahmadi, M. and Roy, R. (2016) AMPK acts as a molecular trigger to coordinate glutamatergic signals and resulting adaptive behaviours in response to starvation. eLIFE. 5. pii: e16349. doi: 10.7554/eLife.16349

Ahmadi, M. and Roy, R. (2016) 5'-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans. In AMPK Springer EXS. 2016;107:375-388

Hand S., Denlinger D., Podrabsky, J.E. and Roy, R. (2016) Mechanisms of Animal Diapause: Recent Developments from nematodes, crustaceans, insects, and fish. Am. J. Physlol. 310: R1193-1211.

Colella, E., Li, S. and Roy, R. (2016) Developmental and Cell Cycle Quiescence is Mediated by the Nuclear Hormone Receptor Coregulator DIN-1S in the C. elegans dauer larva. Genetics, 203:1763-1776.

Xie M, Roy R. (2015) The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans.PLoS Genetics 11: e1005284.

Xie M, Roy R. (2015) AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae. PLoS One 10: e0130480.

Lu Y, Roy R. (2014) Centrosome/Cell Cycle Uncoupling and Elimination in the Endoreduplicating Intestinal Cells of C. elegans. PLoS One. 9(10): e110958. doi: 10.1371.

Xie M, Roy R (2012) Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae. Cell Metabolism 16:322-35.

Roy, R and Mantovani J (2011) Re-evaluating the general(ized) roles of AMPK in cellular metabolism. FEBS, 2011. 585: 967-72.

Narbonne P, Hyenne V, Li S., Labbé J.C., Roy R. (2010) Differential requirements for Strad in LKB1-dependent functions in C. elegans. Development 137: 661-670.

Kim J.S., Hung, W., Narbonne P., Roy R., Zhen M. (2010) C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization. Development 137: 93-102.

Narbonne P., Roy R. (2009) Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Nature 457: 210-214.

Narbonne P, Roy R. (2009) AMP-activated protein kinase (AMPK) allows prolonged energy storage! Med Sci (Paris); 25:565-566

Hebeisen M., Drysdale J., Roy R. (2008) Suppressors of the cdc-25.1(gf)-associated intestinal hyperplasia reveal important maternal roles for prp-8 and a subset of splicing factors in C. elegans. RNA 14: 2618-2633.

Ouellet J., Li S., Roy R. (2008) Notch signalling is required for both dauer maintenance and recovery in C. elegans. Development 135:2583-2592. (funded by the NCIC) Development. 135: 2583-2592.

Hebeisen M. and Roy R. (2008) CDC-25.1 stability is regulated by distinct domains to restrict cell division during embryogenesis in C. elegans. Development 135:1259-1269.

Narbonne P. and Roy R. (2008) Genes that affect both cell growth and polarity mediate stem cell quiescence. Frontiers in Bioscience 13: 995-1002.

Ouellet, J. and Roy R. (2007) The lin-35/Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegansBMC Dev. Biol. 7:38.

Narbonne P., Roy R. (2006) Regulation of germline stem cell proliferation downstream of nutrient sensing. Cell Div. 1: 29-38.

Kim, D.Y. and Roy, R. (2006) Cell cycle regulators control centrosome elimination during oogenesis in Caenorhabditis elegans. J. Cell Biol. 174: 751-757.

Labbé J.C. and Roy R. (2006) New developmental insights from high throughput biological analysis in C. elegans. J. Clin. Genetics 69:306-314.

Narbonne P., Roy R. (2006) Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. Development 133: 611-619. (recommended by Faculty of 1000)

Inoue T., Hirata K., Kuwana Y., Fujita M., Miwa J., Roy R., Yamaguchi Y. (2006) Cell cycle control by daf-21/Hsp90 at the first meiotic prophase/metaphase boundary during oogenesis in Caenorhabditis elegans. Development, Growth and Differentiation 48: 25-32.

Jenna S, Caruso ME, Emadali A, Nguyên DT, Dominguez M, Li S, Roy R., Reboul J., Vidal M., Tzimas G. N., Bossé R. and Chevet E. (2005) Regulation of membrane trafficking by a novel Cdc42-related protein in Caenorhabditis elegans epithelial cells. Mol. Biol. Cell. 16:1629-39.

Kostic I., Li S. and Roy R. (2003) cki-1 links cell division and cell fate acquisition in the C. elegans somatic gonad. Dev. Biol. 263: 242-252. (funded by the NCIC)

Li S, Dent JA and Roy R. (2003) Regulation of intermuscular electrical coupling by the Caenorhabditis elegans innexin inx-6. Mol Biol Cell. 2003 Jul;14(7):2630-44.

Kostic I, Roy R. (2002) Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in C. elegans. Development 129: 2155-2165.

Hong Y.*, Roy R.*, Ambros V. (1998) Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in C. elegans. Development 125: 3585-3597.