Publications

Wong C. and Roy R. (2020) AMPK Regulates Developmental Plasticity through an Endogenous Small RNA Pathway in Caenorhabditis elegans. Int J Mol Sci. 2020 Mar 24;21(6):2238. Doi: 10.339./ijms21062238

Schmeisser S., Li S., Bouchard B., Ruiz M., Rosiers C.D., Roy R. (2019) Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling. Cell Reports 29: 13. doi: https://doi.org/10.1016/j.celrep.2019.11.090.

Kadekar P. and Roy R. (2019) AMPK regulates germline stem cell quiescence and integrity through an endogenous small RNA pathway. PLoS Biol 17: 6. doi: 10.1371/journal.pbio.3000309.

Kadekar P., Chaouni R., Clark E., Kazanets A., Roy R. (2018) Genome-wide surveys reveal polarity and cytoskeletal regulators mediate LKB1-associated germline stem cell quiescence. BMC Genomics 19: 462. doi: 10.1186/s12864-018-4847-y.

Demoinet E., and Roy, R. (2018) Analysis of Transgenerational Phenotypes Following Acute Starvation in AMPK-Deficient C. elegans. Methods Mol Biol. 1732: 565. doi: 10.1007/978-1-4939-7598-3_36.

Demoinet E., and Roy, R. (2018) Surviving Starvation: AMPK blocks starvation-inducible transgenerational defects. Bioessays 40. doi: 10.1002/bies.201700095.

Demoinet E, Li, S., and Roy, R. (2017) AMPK blocks starvation-inducible transgenerational defects. Proc Natl Acad Sci 114, e2689-2698 doi: 10.1073/pnas.1616171114.

Ahmadi, M. and Roy, R. (2016) AMPK acts as a molecular trigger to coordinate glutamatergic signals and resulting adaptive behaviours in response to starvation. eLIFE. 5. pii: e16349. doi: 10.7554/eLife.16349

Ahmadi, M. and Roy, R. (2016) 5′-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans. In AMPK Springer EXS. 2016;107:375-388

Hand S., Denlinger D., Podrabsky, J.E. and Roy, R. (2016) Mechanisms of Animal Diapause: Recent Developments from nematodes, crustaceans, insects, and fish. Am. J. Physlol. 310: R1193-1211.

Colella, E., Li, S. and Roy, R. (2016) Developmental and Cell Cycle Quiescence is Mediated by the Nuclear Hormone Receptor Coregulator DIN-1S in the C. elegans dauer larva. Genetics, 203:1763-1776.

Xie M, Roy R. (2015) The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans.PLoS Genetics 11: e1005284.

Xie M, Roy R. (2015) AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae. PLoS One 10: e0130480.

Lu Y, Roy R. (2014) Centrosome/Cell Cycle Uncoupling and Elimination in the Endoreduplicating Intestinal Cells of C. elegans. PLoS One. 9(10): e110958. doi: 10.1371.

Xie M, Roy R (2012) Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae. Cell Metabolism 16:322-35.

Roy, R and Mantovani J (2011) Re-evaluating the general(ized) roles of AMPK in cellular metabolism. FEBS, 2011. 585: 967-72.

Narbonne P, Hyenne V, Li S., Labbé J.C., Roy R. (2010) Differential requirements for Strad in LKB1-dependent functions in C. elegans. Development 137: 661-670.

Kim J.S., Hung, W., Narbonne P., Roy R., Zhen M. (2010) C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization. Development 137: 93-102.

Narbonne P., Roy R. (2009) Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Nature 457: 210-214.

Narbonne P, Roy R. (2009) AMP-activated protein kinase (AMPK) allows prolonged energy storage! Med Sci (Paris); 25:565-566

Hebeisen M., Drysdale J., Roy R. (2008) Suppressors of the cdc-25.1(gf)-associated intestinal hyperplasia reveal important maternal roles for prp-8 and a subset of splicing factors in C. elegans. RNA 14: 2618-2633.

Ouellet J., Li S., Roy R. (2008) Notch signalling is required for both dauer maintenance and recovery in C. elegans. Development 135:2583-2592. (funded by the NCIC) Development. 135: 2583-2592.

Hebeisen M. and Roy R. (2008) CDC-25.1 stability is regulated by distinct domains to restrict cell division during embryogenesis in C. elegans. Development 135:1259-1269.

Narbonne P. and Roy R. (2008) Genes that affect both cell growth and polarity mediate stem cell quiescence. Frontiers in Bioscience 13: 995-1002.

Ouellet, J. and Roy R. (2007) The lin-35/Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegansBMC Dev. Biol. 7:38.

Narbonne P., Roy R. (2006) Regulation of germline stem cell proliferation downstream of nutrient sensing. Cell Div. 1: 29-38.

Kim, D.Y. and Roy, R. (2006) Cell cycle regulators control centrosome elimination during oogenesis in Caenorhabditis elegans. J. Cell Biol. 174: 751-757.

Labbé J.C. and Roy R. (2006) New developmental insights from high throughput biological analysis in C. elegans. J. Clin. Genetics 69:306-314.

Narbonne P., Roy R. (2006) Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. Development 133: 611-619. (recommended by Faculty of 1000)

Inoue T., Hirata K., Kuwana Y., Fujita M., Miwa J., Roy R., Yamaguchi Y. (2006) Cell cycle control by daf-21/Hsp90 at the first meiotic prophase/metaphase boundary during oogenesis in Caenorhabditis elegans. Development, Growth and Differentiation 48: 25-32.

Emadali D., Nguyên T., Dominguez M., Li S., Roy R., Reboul J., Vidal M., Tzimas G. N., Bossé R. and Chevet E. (2005) Regulation of membrane trafficking by a novel Cdc42-related protein in Caenorhabditis elegans epithelial cells. Mol. Biol. Cell. 16:1629-39.

Kostic I., Li S. and Roy R. (2003) cki-1 links cell division and cell fate acquisition in the C. elegans somatic gonad. Dev. Biol. 263: 242-252. (funded by the NCIC)

Kostic I, Roy R. (2002) Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in C. elegans. Development 129: 2155-2165.

Hong Y.*, Roy R.*, Ambros V. (1998) Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in C. elegans. Development 125: 3585-3597.